Which one should I pick for a new project?

I can only answer questions about honojs/hono or ruvnet/ruflo specifically.

To help you decide between them, I'd need to know what you're building. Here's what each project is for:

[honojs/hono] is a web framework — a small, fast, lightweight framework built on Web Standards that works across multiple JavaScript runtimes (Cloudflare Workers, Deno, Bun, Node.js, etc.). Use this if you're building HTTP APIs or web services.

[ruvnet/ruflo] appears to be an AI agent orchestration system — it's built around multi-agent workflows, LLM integration (Claude, OpenAI), and distributed consensus. The package.json shows dependencies for @opentelemetry (observability), grpc, vector databases, and agent frameworks. Use this if you're building intelligent agent systems or agentic workflows.

Pick Hono if: you need a fast, lightweight web framework for APIs/services. Pick Ruflo if: you need to orchestrate AI agents or build agentic workflows.

These aren't competing projects—they solve different problems. Ruflo could potentially use Hono as its HTTP foundation, though there's no indication of that in the code shown.

What are you trying to build?

FOLLOW_UPS:

• Does Ruflo depend on Hono for HTTP?
• What are Ruflo's core agent orchestration patterns?
• How do Hono's runtimes compare to Node.js?